| Pair Name | Corylin, Etoposide | ||
| Phytochemical Name | Corylin (PubChem CID: 5316097 ) | ||
| Anticancer drug Name | Etoposide (PubChem CID: 36462 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Corylin, Etoposide | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Up-regulation | Cleavage | CASP3 | hsa836 |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Down-regulation | Expression | RAD51 | hsa5888 | |
| In Vitro Model | Huh-7 | Adult hepatocellular carcinoma | Homo sapiens (Human) | CVCL_0336 |
| Hep-G2 | Hepatoblastoma | Homo sapiens (Human) | CVCL_0027 | |
| In Vivo Model | A total of 4×10⁶ Huh7 cells were resuspended in 100 μl of saline with 50% Matrigel, and the suspensions were subcutaneously implanted into the left and right flank regions of the mice. | |||
| Result | Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair | |||
| No. | Title | Href |
|---|---|---|
| 1 | Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. Cell Death Dis. 2018 May 1;9(5):543. doi: 10.1038/s41419-018-0575-0. | Click |
